Issues

• Serve splicing and NMD detection as assay facts in API responses

  app: backendapp: databaseapp: frontend
  Feature

  VariantEffect/mavedb-api#924 · Filter by author bencap opened on Oct 14, 2026 · R2026.4

• Let API clients list official collections and filter score set search by them

  app: backend
  Feature

  VariantEffect/mavedb-api#923 · Filter by author bencap opened on Oct 14, 2026 · R2026.4

• Model ClinGen alleles like other external sources

  app: databaseapp: worker
  Epic

  VariantEffect/mavedb-api#922 · Filter by author bencap opened on Oct 12, 2026

• Score set 00000663-a-1's nucleotide variants are two bases off from their protein variants

  app: database
  Bug

  VariantEffect/mavedb-api#921 · Filter by author bencap opened on Oct 12, 2026 · R2026.4

• Warn at upload when a row's nucleotide and protein variants describe different changes

  app: backend
  Feature

  VariantEffect/mavedb-api#920 · Filter by author bencap opened on Oct 12, 2026 · R2026.4

• Store allele ClinGen allele IDs as valid-time links

  app: backendapp: databaseapp: worker
  Chore

  VariantEffect/mavedb-api#919 · Filter by author bencap opened on Oct 12, 2026 · R2026.4

• Record ClinGen allele facts in the database instead of Redis

  app: databaseapp: worker
  Chore

  VariantEffect/mavedb-api#918 · Filter by author bencap opened on Oct 12, 2026 · R2026.4

• Rate-limit by user and tier in the API, with the WAF as a per-IP backstop

  app: awsapp: backend
  Feature

  VariantEffect/mavedb-api#917 · Filter by author bencap opened on Oct 9, 2026 · R2026.4

• Choose how whole-set responses are cached and revalidated

  app: awsapp: backend
  Spike

  VariantEffect/mavedb-api#916 · Filter by author bencap opened on Oct 9, 2026 · R2026.4

• Build bulk response rows without validating each through Pydantic

  app: backend
  Chore

  VariantEffect/mavedb-api#915 · Filter by author bencap opened on Oct 9, 2026 · R2026.4

• Measure where time and bytes go when serving whole score sets

  app: backend
  Spike

  VariantEffect/mavedb-api#914 · Filter by author bencap opened on Oct 9, 2026 · R2026.4

• Decide whether VRS identifiers should be the canonical variant-page link

  app: backendapp: frontend
  Spike

  VariantEffect/mavedb-api#912 · Filter by author bencap opened on Oct 8, 2026 · R2026.4

• Give variants without a ClinGen allele ID a variant page

  app: backendapp: frontend
  Feature

  VariantEffect/mavedb-api#911 · Filter by author bencap opened on Oct 8, 2026 · R2026.4

• Tell calibration editors when a score re-upload drops their controls

  app: backendapp: databaseapp: frontendapp: worker
  Feature

  VariantEffect/mavedb-api#910 · Filter by author bencap opened on Oct 7, 2026

• Update Dockerfile to use latest version of poetry (2.5.1 at time of writing)

  app: backend
  VariantEffect/mavedb-api#909 · Filter by author davereinhart opened on Oct 2, 2026

• Update Dockerfile latest version of python 3 (3.14 at time of writing)

  app: backend
  VariantEffect/mavedb-api#908 · Filter by author davereinhart opened on Oct 2, 2026

• Keep the API responsive under heavy downloads and large score sets

  app: backend
  Epic

  VariantEffect/mavedb-api#906 · Filter by author bencap opened on Sep 29, 2026

• Return 503 when the database drops a request's connection

  app: backend
  Bug

  VariantEffect/mavedb-api#905 · Filter by author bencap opened on Sep 29, 2026 · R2026.4

• Protect the lean variant view like the CSV download routes

  app: awsapp: backend
  Task

  VariantEffect/mavedb-api#904 · Filter by author bencap opened on Sep 29, 2026 · R2026.4

• Decide how CSV exports pick between two ClinVar records for one allele

  app: backendapp: database
  Spike

  VariantEffect/mavedb-api#903 · Filter by author bencap opened on Sep 29, 2026 · R2026.4

• Remove the CSV build cap

  app: backend
  Chore

  VariantEffect/mavedb-api#902 · Filter by author bencap opened on Sep 29, 2026

• Page score set downloads without walking every skipped row

  app: backend
  Chore

  VariantEffect/mavedb-api#901 · Filter by author bencap opened on Sep 29, 2026 · R2026.4

• Statistics count routes time out

  app: backendapp: database
  Bug

  VariantEffect/mavedb-api#900 · Filter by author bencap opened on Sep 29, 2026 · R2026.4

• Enforce publication invariants with database constraints

  app: backendapp: database
  Chore

  VariantEffect/mavedb-api#893 · Filter by author bencap opened on Sep 28, 2026 · R2026.4

• Move type definitions out of the central lib/types folder and next to their code

  app: backendapp: worker
  Chore

  VariantEffect/mavedb-api#892 · Filter by author bencap opened on Sep 25, 2026 · R2026.4