diff --git a/.github/workflow-scripts/addDescriptiveLabels.js b/.github/workflow-scripts/addDescriptiveLabels.js
index 4493fbb48c63..a7286eb9b695 100644
--- a/.github/workflow-scripts/addDescriptiveLabels.js
+++ b/.github/workflow-scripts/addDescriptiveLabels.js
@@ -109,7 +109,6 @@ const apis = [
   'ImageEditor',
   'ImagePickerIOS',
   'ImageStore',
-  'InteractionManager',
   'Keyboard',
   'LayoutAnimation',
   'Linking',
diff --git a/packages/react-native-babel-preset/src/configs/lazy-imports.js b/packages/react-native-babel-preset/src/configs/lazy-imports.js
index 95cb75e262c2..bf074011e909 100644
--- a/packages/react-native-babel-preset/src/configs/lazy-imports.js
+++ b/packages/react-native-babel-preset/src/configs/lazy-imports.js
@@ -62,7 +62,6 @@ module.exports = new Set([
   'Easing',
   'ReactNative',
   'I18nManager',
-  'InteractionManager',
   'Keyboard',
   'LayoutAnimation',
   'Linking',
diff --git a/packages/react-native/index.js b/packages/react-native/index.js
index 69c3f67ca8b1..27d8189d48f3 100644
--- a/packages/react-native/index.js
+++ b/packages/react-native/index.js
@@ -27,7 +27,6 @@
 import typeof * as ReactNativePublicAPI from './index.js.flow';
 
 const warnOnce = require('./Libraries/Utilities/warnOnce').default;
-const invariant = require('invariant');
 
 module.exports = {
   // #region Components
@@ -386,21 +385,3 @@ module.exports = {
   },
   // #endregion
 } as ReactNativePublicAPI;
-
-if (__DEV__) {
-  /* $FlowFixMe[prop-missing] This is intentional: Flow will error when
-   * attempting to access InteractionManager. */
-  /* $FlowFixMe[invalid-export] This is intentional: Flow will error when
-   * attempting to access InteractionManager. */
-  Object.defineProperty(module.exports, 'InteractionManager', {
-    configurable: true,
-    get() {
-      invariant(
-        false,
-        'InteractionManager has been removed from react-native core. ' +
-          'Please refactor long tasks into smaller ones, and use ' +
-          "'requestIdleCallback' instead.",
-      );
-    },
-  });
-}