diff --git a/docs/upgrade.rst b/docs/upgrade.rst
index 236494a5cd..196e999651 100644
--- a/docs/upgrade.rst
+++ b/docs/upgrade.rst
@@ -420,14 +420,14 @@ constructors prevent such mistakes. See :ref:`custom_constructors` for details.
    though no C++ object has been constructed there yet. Accessing the storage through such
    a pointer as though it contained a live C++ object results in undefined behavior.
 
-   Consequently, until placement-new completes, the binding must not otherwise load or inspect
-   the instance as a C++ object. Unsafe access can occur through reentrant argument conversion
-   or callback code, nested initialization, another C++ base in a Python multiple-inheritance
-   instance, or concurrent access. Mixing old- and new-style constructor overloads does not
-   narrow the window. Such access may treat unconstructed storage as a live object and result
-   in undefined behavior. To avoid these hazards, use ``py::init()`` factories and
-   ``py::pickle()`` for new bindings, and migrate existing placement-new callbacks wherever
-   practical.
+   Consequently, while such a constructor overload chain is active, the binding must not otherwise
+   load or inspect an unconstructed value slot as a C++ object. Unsafe access can occur through
+   reentrant argument conversion or callback code, nested initialization, another C++ base in a
+   Python multiple-inheritance instance, or concurrent access. Mixing old- and new-style
+   constructor overloads does not narrow the window. Such access may treat unconstructed storage
+   as a live object and result in undefined behavior. To avoid these hazards, use ``py::init()``
+   factories and ``py::pickle()`` for new bindings, and migrate existing placement-new callbacks
+   wherever practical.
 
 Mirroring the custom constructor changes, ``py::pickle()`` is now the preferred
 way to get and set object state. See :ref:`pickling` for details.
diff --git a/include/pybind11/detail/type_caster_base.h b/include/pybind11/detail/type_caster_base.h
index 65b6bd07df..14b3feb389 100644
--- a/include/pybind11/detail/type_caster_base.h
+++ b/include/pybind11/detail/type_caster_base.h
@@ -545,23 +545,33 @@ PYBIND11_NOINLINE void instance::deallocate_layout() {
 /// reference from `docs/advanced/classes.rst`: the broad scope preserves historical behavior,
 /// with documented reentrancy, multiple-inheritance, nesting, and concurrency limitations.
 ///
-/// If construction fails (the holder was never constructed) after storage was lazily allocated
-/// inside this scope, the destructor frees that storage and resets the value pointer, so that the
-/// uninitialized-value guard in `load_value()` stays effective for later uses of the instance.
+/// When the scope exits, the destructor frees storage that was lazily allocated in any value slot
+/// that was empty on entry and whose holder was never constructed. This keeps the uninitialized-
+/// value guard in `load_value()` effective for later uses of the instance, including sibling slots
+/// in a Python multiple-inheritance layout.
 class old_style_init_scope {
 public:
-    explicit old_style_init_scope(value_and_holder *v_h) : v_h_{v_h} {
-        if (v_h_ != nullptr) {
-            was_active_ = v_h_->inst->old_style_init_active;
-            value_was_null_ = v_h_->value_ptr() == nullptr;
-            v_h_->inst->old_style_init_active = true;
+    explicit old_style_init_scope(value_and_holder *v_h)
+        : inst_{v_h != nullptr ? v_h->inst : nullptr} {
+        if (inst_ != nullptr) {
+            values_and_holders vhs(inst_);
+            empty_slots_.reserve(vhs.size());
+            for (auto &slot : vhs) {
+                if (slot.value_ptr() == nullptr) {
+                    empty_slots_.push_back(slot);
+                }
+            }
+            was_active_ = inst_->old_style_init_active;
+            inst_->old_style_init_active = true;
         }
     }
     ~old_style_init_scope() {
-        if (v_h_ != nullptr) {
-            v_h_->inst->old_style_init_active = was_active_;
-            if (value_was_null_ && !v_h_->holder_constructed() && v_h_->value_ptr() != nullptr) {
-                v_h_->type->dealloc(*v_h_); // Frees the storage and nulls the value pointer.
+        if (inst_ != nullptr) {
+            inst_->old_style_init_active = was_active_;
+            for (auto &slot : empty_slots_) {
+                if (!slot.holder_constructed() && slot.value_ptr() != nullptr) {
+                    slot.type->dealloc(slot); // Frees the storage and nulls the value pointer.
+                }
             }
         }
     }
@@ -569,9 +579,9 @@ class old_style_init_scope {
     old_style_init_scope &operator=(const old_style_init_scope &) = delete;
 
 private:
-    value_and_holder *v_h_;
+    instance *inst_;
+    std::vector<value_and_holder> empty_slots_;
     bool was_active_ = false;
-    bool value_was_null_ = false;
 };
 
 PYBIND11_NOINLINE bool isinstance_generic(handle obj, const std::type_info &tp) {
diff --git a/tests/test_class.cpp b/tests/test_class.cpp
index 21ff617365..47430d3a29 100644
--- a/tests/test_class.cpp
+++ b/tests/test_class.cpp
@@ -650,6 +650,7 @@ TEST_SUBMODULE(class_, m) {
     // This probe intentionally does not dereference the pointer. It documents the narrow scope of
     // this fix without itself reading storage before an OldStyleInit lifetime has begun.
     m.def("expose_old_style_init_pointer", [](OldStyleInit *value) { return value != nullptr; });
+    m.def("expose_new_no_init_pointer", [](NewNoInit *value) { return value != nullptr; });
 }
 
 template <int N>
diff --git a/tests/test_class.py b/tests/test_class.py
index 645b799c9f..638053b494 100644
--- a/tests/test_class.py
+++ b/tests/test_class.py
@@ -338,6 +338,35 @@ def __index__(self):
     assert obj.data() == 44
 
 
+def test_old_style_init_cleans_multiple_inheritance_sibling_storage():
+    """The old-style compatibility window is instance-wide, so a reentrant load can lazily
+    allocate an unconstructed sibling base slot. Scope cleanup must reset that slot too."""
+
+    class Derived(m.OldStyleInit, m.NewNoInit):
+        pass
+
+    obj = Derived.__new__(Derived)
+    seen = {}
+
+    class LoadSiblingOnIndex:
+        def __index__(self):
+            # Deliberately obtain but do not dereference the sibling's unconstructed storage.
+            seen["exposed"] = m.expose_new_no_init_pointer(obj)
+            return 45
+
+    m.OldStyleInit.__init__(obj, LoadSiblingOnIndex())
+
+    assert seen == {"exposed": True}
+    assert m.OldStyleInit.data(obj) == 45
+    with pytest.raises(ValueError, match="uninitialized"):
+        m.expose_new_no_init_pointer(obj)
+
+    # The sibling slot remains usable after the old-style constructor returns.
+    m.NewNoInit.__init__(obj, 46)
+    assert m.OldStyleInit.data(obj) == 45
+    assert m.NewNoInit.data(obj) == 46
+
+
 def test_reentrant_load_during_new_style_init():
     """New-style constructors never need lazy allocation, so passing the half-built instance
     to another bound function while `__init__` runs must raise, not hand out garbage."""