diff --git a/CHANGELOG.md b/CHANGELOG.md
index 0c1adbbe9..43e5995cb 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,11 @@
 
 ## New functionality
 
+* Added `methods/bernn` (Batch Effect Removal Neural Network).
+    - Adds a neural-network-based integration method designed to reduce batch effects
+      while preserving biological information using cell type labels.
+    - Registers BERNN in the batch integration benchmark workflow.
+
 * Added `metrics/kbet_pg` and `metrics/kbet_pg_label` components (PR #52).
 * Add `methods/ss_stacas` new method (PR #59).
     - Add semi-supervised version of STACAS tool for integration of single-cell transcriptomics data. This functionality leverages partial or imperfect knowledge of cell identity to improve integration quality by preserving biological variation while correcting for batch effects.
diff --git a/_viash.yaml b/_viash.yaml
index f4a5a7c2a..3ece12967 100644
--- a/_viash.yaml
+++ b/_viash.yaml
@@ -46,6 +46,11 @@ info:
       dest: resources_test/task_batch_integration
 
 authors:
+  - name: Simon Pelletier
+    roles: [contributor]
+    info:
+      github: spell00
+      orcid: "0000-0003-2515-1633"
   - name: Michaela Mueller
     roles: [ maintainer, author ]
     info:
diff --git a/src/methods/bernn/config.vsh.yaml b/src/methods/bernn/config.vsh.yaml
new file mode 100644
index 000000000..4671c6f46
--- /dev/null
+++ b/src/methods/bernn/config.vsh.yaml
@@ -0,0 +1,81 @@
+__merge__: /src/api/comp_method.yaml
+name: bernn
+label: BERNN
+summary: Batch Effect Removal Neural Network using supervised biological labels and batch domains.
+description: |
+  BERNN (Batch Effect Removal Neural Network) is a modality-agnostic
+  deep learning framework combining supervised classification with
+  unsupervised representation learning to reduce batch effects while
+  preserving predictive information. Originally developed using
+  LC-MS proteomics data, BERNN learns a low-dimensional representation
+  through autoencoder reconstruction and classification objectives.
+  It can be applied across data modalities when batch assignments
+  and classification targets are available. In this benchmark,
+  cell types serve as classification targets.
+references:
+  doi: 10.1038/s41467-024-48177-5
+links:
+  repository: https://github.com/spell00/BERNN_MSMS
+  documentation: https://pypi.org/project/bernn/
+info:
+  method_types: [embedding]
+  preferred_normalization: log_cp10k
+  variants:
+    bernn_default:
+arguments:
+  - name: --n_hvg
+    type: integer
+    default: 2000
+    description: Number of highly variable genes to use.
+  - name: --n_epochs
+    type: integer
+    default: 200
+    description: Maximum number of BERNN training epochs.
+    info:
+      test_default: 10
+  - name: --warmup
+    type: integer
+    default: 50
+    description: Number of unsupervised warmup epochs.
+    info:
+      test_default: 5
+  - name: --early_stop
+    type: integer
+    default: 5
+    description: Stop joint BERNN training after this many epochs without improvement.
+  - name: --early_warmup_stop
+    type: integer
+    default: 5
+    description: Stop BERNN warmup after this many epochs without improvement.
+  - name: --batch_size
+    type: integer
+    default: 1024
+    description: Training batch size used by the selected OpenProblems BERNN configuration.
+  - name: --n_layers
+    type: integer
+    default: 2
+    description: Number of hidden layers.
+  - name: --layer1
+    type: integer
+    default: 512
+    description: Width of the first hidden layer.
+  - name: --dloss
+    type: string
+    default: inverseTriplet
+    choices: [inverseTriplet, revTriplet, DANN, revDANN, normae, no]
+    description: Batch-effect loss used by BERNN.
+resources:
+  - type: python_script
+    path: script.py
+  - path: /src/utils/read_anndata_partial.py
+engines:
+  - type: docker
+    image: openproblems/base_pytorch_nvidia:1
+    setup:
+      - type: docker
+        run: pip install --no-cache-dir tensorboardX scikit-optimize shapely && pip install --no-cache-dir --no-deps git+https://github.com/spell00/BERNN_MSMS.git@897c194d3a58f6ab529cc0e6afd4117a813a2a65
+runners:
+  - type: executable
+  - type: nextflow
+    directives:
+      label: [veryhightime, midmem, lowcpu, gpu]
diff --git a/src/methods/bernn/script.py b/src/methods/bernn/script.py
new file mode 100644
index 000000000..24dd5bc6f
--- /dev/null
+++ b/src/methods/bernn/script.py
@@ -0,0 +1,291 @@
+import sys
+import anndata as ad
+import numpy as np
+import pandas as pd
+import torch
+
+# Memory-efficient OpenProblems BERNN adapter uses BERNN internals below.
+
+## VIASH START
+par = {
+    "input": "resources_test/task_batch_integration/cxg_immune_cell_atlas/dataset.h5ad",
+    "output": "output.h5ad",
+    "n_hvg": 2000,
+    "n_epochs": 200,
+    "warmup": 50,
+    "early_stop": 5,
+    "early_warmup_stop": 5,
+    "batch_size": 1024,
+    "n_layers": 2,
+    "layer1": 512,
+    "dloss": "inverseTriplet",
+}
+meta = {"name": "bernn"}
+## VIASH END
+
+sys.path.append(meta["resources_dir"])
+from read_anndata_partial import read_anndata
+
+import gc
+from sklearn.preprocessing import StandardScaler
+from bernn.openproblems import (
+    TrainingConfig,
+    _OpenProblemsFinalEpochTrainer,
+    _dense_frame,
+    _select_feature_indices,
+)
+import bernn.dl.train.train_ae_classifier_holdout as _bernn_holdout_module
+
+_ORIGINAL_BERNN_SCALE_DATA = _bernn_holdout_module.scale_data
+
+
+def _memory_efficient_standard_scale_data(scale, data, device="cpu"):
+    # OpenProblems BERNN uses standard scaling. Scale the full train matrix once
+    # in float32 and reuse it as "all" instead of materializing train/valid/test/all.
+    if scale != "standard":
+        return _ORIGINAL_BERNN_SCALE_DATA(scale, data, device)
+
+    train = data["inputs"]["train"]
+    scaler = StandardScaler()
+    scaler.fit(np.asarray(train, dtype=np.float32))
+
+    for group in ("train", "valid", "test"):
+        current = data["inputs"].get(group)
+        if current is None or current.shape[0] == 0:
+            continue
+        columns = current.columns
+        index = current.index
+        values = np.asarray(current, dtype=np.float32)
+        values = scaler.transform(values).astype(np.float32, copy=False)
+        data["inputs"][group] = pd.DataFrame(values, columns=columns, index=index)
+
+    data["inputs"]["all"] = data["inputs"]["train"]
+    return data, scaler
+
+
+class _MemoryEfficientOpenProblemsTrainer(_OpenProblemsFinalEpochTrainer):
+    def _alias_all_to_train(self):
+        if self.data is None:
+            return
+        for key in ("inputs", "names", "labels", "cats", "batches", "orders", "sets"):
+            if key in self.data and "train" in self.data[key]:
+                self.data[key]["all"] = self.data[key]["train"]
+
+    def _prepare_data(self, *args, **kwargs):
+        super()._prepare_data(*args, **kwargs)
+        if getattr(self, "_no_internal_validation", False):
+            self._alias_all_to_train()
+            gc.collect()
+
+    def make_samples_weights(self):
+        super().make_samples_weights()
+        if getattr(self, "_no_internal_validation", False):
+            self._alias_all_to_train()
+            gc.collect()
+
+
+def _fit_openproblems_memory_efficient_once(
+    adata,
+    *,
+    layer="normalized",
+    batch_key="batch",
+    label_key="cell_type",
+    n_hvg=2000,
+    dloss="inverseTriplet",
+    n_epochs=200,
+    warmup=50,
+    early_stop=5,
+    early_warmup_stop=5,
+    batch_size=256,
+    n_layers=2,
+    layer1=256,
+    scaler="standard",
+    learning_rate=1e-3,
+    weight_decay=1e-5,
+    dropout=0.1,
+    margin=1.0,
+    smoothing=0.1,
+    nu=1.0,
+    random_state=1,
+    num_workers=0,
+    device=None,
+    return_trainer=False,
+):
+    if batch_key not in adata.obs:
+        raise KeyError(f"AnnData obs is missing required batch key {batch_key!r}")
+    if label_key not in adata.obs:
+        raise KeyError(f"AnnData obs is missing required label key {label_key!r}")
+
+    feature_idx = _select_feature_indices(adata, n_hvg)
+    frame = _dense_frame(adata, feature_idx, layer)
+    labels = adata.obs[label_key].astype(str).to_numpy()
+    batches = adata.obs[batch_key].astype(str).to_numpy()
+
+    # BERNN training loaders use drop_last=True. When the batch size exceeds
+    # the dataset size, train_classifier returns None because there are no batches.
+    # Preserve the requested batch size on large datasets and use two full
+    # batches on smaller datasets, including the 600-cell Viash fixture.
+    requested_bs = int(batch_size)
+    batch_size = min(requested_bs, max(2, len(frame) // 2))
+    if batch_size != requested_bs:
+        print(f"BERNN: batch size {requested_bs} -> {batch_size} for {len(frame)} cells", flush=True)
+
+    # The dense float32 frame is now the training source of truth. Release the
+    # input expression matrix before BERNN creates training tensors.
+    if layer in ("X", None):
+        try:
+            adata.X = None
+        except Exception:
+            pass
+    gc.collect()
+
+    if device is None:
+        device = "cuda" if torch.cuda.is_available() else "cpu"
+
+    config = TrainingConfig(
+        optimize_hyperparams=False, dloss=dloss, class_triplet=False,
+        variational=False, kan=False, n_layers=int(n_layers), layer1=int(layer1),
+        tied_weights=False, use_mapping=True, rec_loss="l1", scaler=scaler,
+        log1p=False, use_l1=True, prune_network=False, update_grid=False,
+        n_epochs=int(n_epochs), warmup=int(warmup), n_repeats=1,
+        bs=int(batch_size), num_workers=int(num_workers), groupkfold=True,
+        device=device, dataset=str(getattr(adata, "uns", {}).get("dataset_id", "openproblems")),
+        exp_id="bernn_openproblems_exact",
+        early_stop=int(early_stop),
+        early_warmup_stop=int(early_warmup_stop),
+    )
+    config.lr = float(learning_rate)
+    config.wd = float(weight_decay)
+    config.dropout = float(dropout)
+    config.margin = float(margin)
+    config.smoothing = float(smoothing)
+    config.nu = float(nu)
+    config.thres = 0.0
+    config.gamma = 0.1
+    config.beta = 0.0
+
+    trainer = _MemoryEfficientOpenProblemsTrainer(
+        config=config, groupkfold=True, pools=False, keep_models=False,
+        log_inputs=False, log_plots=False, log_tb=False, log_mlflow=False,
+        log_dvclive=False,
+    )
+    params = {
+        "lr": float(learning_rate), "dropout": float(dropout),
+        "wd": float(weight_decay), "margin": float(margin),
+        "smoothing": float(smoothing), "scaler": scaler, "gamma": 0.1,
+        "beta": 0.0, "nu": float(nu), "thres": 0.0,
+        "prune_threshold": 0.0, "warmup": int(warmup), "l1": 0.0,
+        "reg_entropy": 0.0, "layer1": int(layer1),
+        "n_layers": int(n_layers),
+    }
+    for idx in range(2, int(n_layers) + 1):
+        params[f"layer{idx}"] = max(16, int(layer1) // (2 ** (idx - 1)))
+
+    # Small deterministic resubstitution monitors satisfy legacy bookkeeping
+    # without holding full-size valid/test copies. They remain part of train.
+    monitor_n = min(len(frame), max(256, min(1024, int(batch_size))))
+    monitor_idx = np.unique(np.linspace(0, len(frame) - 1, monitor_n, dtype=np.int64))
+    monitor_frame = frame.iloc[monitor_idx]
+    monitor_labels = labels[monitor_idx]
+    monitor_batches = batches[monitor_idx]
+
+    _bernn_holdout_module.scale_data = _memory_efficient_standard_scale_data
+    try:
+        trainer.fit(
+            frame,
+            labels,
+            groups_train=batches,
+            X_valid=monitor_frame,
+            y_valid=monitor_labels,
+            groups_valid=monitor_batches,
+            X_test=monitor_frame,
+            y_test=monitor_labels,
+            groups_test=monitor_batches,
+            params=params,
+            internal_validation=False,
+        )
+    finally:
+        _bernn_holdout_module.scale_data = _ORIGINAL_BERNN_SCALE_DATA
+
+    trainer.restore_openproblems_final_state()
+
+    # Encode in chunks so inference never creates another full dense copy plus
+    # a second full torch tensor.
+    encoded_parts = []
+    chunk_size = max(2048, int(batch_size) * 4)
+    for start in range(0, len(frame), chunk_size):
+        stop = min(len(frame), start + chunk_size)
+        encoded = trainer.transform(
+            frame.iloc[start:stop],
+            groups_test=batches[start:stop],
+        )
+        encoded_parts.append(np.asarray(encoded, dtype=np.float32))
+    embedding = (
+        np.concatenate(encoded_parts, axis=0)
+        if encoded_parts
+        else np.empty((0, 0), dtype=np.float32)
+    )
+
+    if return_trainer:
+        return embedding, trainer
+    return embedding
+
+
+print("Read input", flush=True)
+adata = read_anndata(
+    par["input"],
+    X="layers/normalized",
+    obs="obs",
+    var="var",
+    uns="uns",
+)
+
+device = "cuda:0" if torch.cuda.is_available() else "cpu"
+print(
+    f"Run BERNN OpenProblems full-dataset fit on {adata.shape[0]} cells x {adata.shape[1]} genes "
+    f"using {device}; no train/valid/test holdout and final epoch output",
+    flush=True,
+)
+
+embedding, trainer = _fit_openproblems_memory_efficient_once(
+    adata,
+    layer="X",
+    batch_key="batch",
+    label_key="cell_type",
+    n_hvg=int(par["n_hvg"]),
+    dloss=str(par["dloss"]),
+    n_epochs=int(par["n_epochs"]),
+    warmup=int(par["warmup"]),
+    early_stop=int(par["early_stop"]),
+    early_warmup_stop=int(par["early_warmup_stop"]),
+    batch_size=int(par["batch_size"]),
+    n_layers=int(par["n_layers"]),
+    layer1=int(par["layer1"]),
+    scaler="standard",
+    learning_rate=1e-3,
+    weight_decay=1e-5,
+    dropout=0.0,
+    margin=1.0,
+    smoothing=0.1,
+    nu=1.0,
+    num_workers=0,
+    device=device,
+    return_trainer=True,
+)
+
+print(
+    f"Extracted final-epoch BERNN embedding after epoch {trainer._openproblems_last_epoch}",
+    flush=True,
+)
+print("Store output", flush=True)
+output = ad.AnnData(
+    obs=adata.obs[[]],
+    var=pd.DataFrame(index=[]),
+    obsm={"X_emb": np.asarray(embedding, dtype=np.float32)},
+    uns={
+        "dataset_id": adata.uns["dataset_id"],
+        "normalization_id": adata.uns["normalization_id"],
+        "method_id": meta["name"],
+    },
+)
+output.write_h5ad(par["output"], compression="gzip")
diff --git a/src/workflows/run_benchmark/config.vsh.yaml b/src/workflows/run_benchmark/config.vsh.yaml
index 48de649f0..a79e91d05 100644
--- a/src/workflows/run_benchmark/config.vsh.yaml
+++ b/src/workflows/run_benchmark/config.vsh.yaml
@@ -91,6 +91,7 @@ dependencies:
   - name: methods/batchelor_fastmnn
   - name: methods/batchelor_mnn_correct
   - name: methods/bbknn
+  - name: methods/bernn
   - name: methods/cellplm
   - name: methods/combat
   - name: methods/combat_seq
diff --git a/src/workflows/run_benchmark/main.nf b/src/workflows/run_benchmark/main.nf
index 11bb3dadd..5090e43c0 100644
--- a/src/workflows/run_benchmark/main.nf
+++ b/src/workflows/run_benchmark/main.nf
@@ -19,6 +19,7 @@ methods = [
   batchelor_fastmnn,
   batchelor_mnn_correct,
   bbknn,
+  bernn,
   cellplm.run(
     args: [model: file("s3://openproblems-work/cache/cellplm-ckpt.zip")]
   ),