diff --git a/.changeset/postcss-fallback.md b/.changeset/postcss-fallback.md
new file mode 100644
index 000000000..aed2a8a5b
--- /dev/null
+++ b/.changeset/postcss-fallback.md
@@ -0,0 +1,5 @@
+---
+'@doc-kit/generator-react': patch
+---
+
+Fall back to PostCSS, rather than Lightning CSS's wasm build, on platforms without native Lightning CSS bindings
diff --git a/packages/react/package.json b/packages/react/package.json
index 3076b67fe..c3ecd2817 100644
--- a/packages/react/package.json
+++ b/packages/react/package.json
@@ -45,7 +45,6 @@
     "hast-util-to-html": "^9.0.5",
     "hast-util-to-string": "^3.0.1",
     "hastscript": "^9.0.1",
-    "lightningcss-wasm": "^1.33.0",
     "mdast-util-slice-markdown": "^2.0.1",
     "preact": "^10.29.7",
     "preact-render-to-string": "^6.7.0",
diff --git a/packages/react/src/html/README.md b/packages/react/src/html/README.md
index caa8610f6..010a5e0fb 100644
--- a/packages/react/src/html/README.md
+++ b/packages/react/src/html/README.md
@@ -301,10 +301,15 @@ export default {
 
 The generator owns the fields required to coordinate its builds: config-file
 loading, app type and base, virtual inputs, Preact compatibility aliases and
-automatic JSX runtime, the Lightning CSS transformer, output/write mode, SSR
-format and output, and SSR dependency bundling. Values supplied for those
-fields are replaced after configuration is merged. User plugins are registered
-after the generator's virtual-module plugin; other Vite options are preserved.
+automatic JSX runtime, the CSS transformer, output/write mode, SSR format and
+output, and SSR dependency bundling. Values supplied for those fields are
+replaced after configuration is merged. User plugins are registered after the
+generator's virtual-module plugin; other Vite options are preserved.
+
+CSS is transformed and minified by Lightning CSS. On platforms without its
+native bindings, such as ppc64 and s390x, Vite's PostCSS pipeline transforms
+the CSS instead and the output is not minified; `css.lightningcss` options have
+no effect there.
 
 Vite builds the client entry as a module, not the pages as HTML entries, so
 plugins see and can transform every module of the client and server builds but
diff --git a/packages/react/src/html/bundlers/__tests__/vite.test.mjs b/packages/react/src/html/bundlers/__tests__/vite.test.mjs
index 676ce4eca..f2c14555b 100644
--- a/packages/react/src/html/bundlers/__tests__/vite.test.mjs
+++ b/packages/react/src/html/bundlers/__tests__/vite.test.mjs
@@ -108,6 +108,21 @@ describe('Vite configuration', () => {
     );
   });
 
+  it('transforms CSS with Lightning CSS where its bindings are native', () => {
+    const config = createViteConfig({
+      sources: new Map(),
+      input: {},
+      server: false,
+      outDir: output,
+      config: getConfig('html'),
+      vite: { css: { lightningcss: { targets: {} } } },
+    });
+
+    assert.strictEqual(config.css.transformer, 'lightningcss');
+    assert.deepStrictEqual(config.css.lightningcss, { targets: {} });
+    assert.strictEqual(config.build.cssMinify, undefined);
+  });
+
   it('keeps the server library self-contained', () => {
     const vite = {
       ssr: {
diff --git a/packages/react/src/html/bundlers/vite.mjs b/packages/react/src/html/bundlers/vite.mjs
index 3f7c83353..aae767da1 100644
--- a/packages/react/src/html/bundlers/vite.mjs
+++ b/packages/react/src/html/bundlers/vite.mjs
@@ -2,7 +2,6 @@ import { readFile, rm, rmdir } from 'node:fs/promises';
 import { dirname, join, posix, resolve } from 'node:path';
 import { fileURLToPath, pathToFileURL } from 'node:url';
 
-import './wasm-fallback.mjs';
 import {
   build as viteBuild,
   defaultClientConditions,
@@ -138,6 +137,9 @@ export const createViteConfig = ({
   const root = resolve(vite.root ?? process.cwd());
   const conditions = server ? defaultServerConditions : defaultClientConditions;
 
+  // Lightning CSS publishes no native bindings for these platforms
+  const lightningcss = process.arch !== 'ppc64' && process.arch !== 's390x';
+
   return {
     ...vite,
 
@@ -194,15 +196,21 @@ export const createViteConfig = ({
     },
 
     // CSS imports, modules, URLs, splitting, and minification are all Vite
-    // responsibilities. Native Lightning CSS options remain configurable.
+    // responsibilities. Lightning CSS transforms the CSS, with its options
+    // configurable, on platforms that have its native bindings; elsewhere
+    // Vite's PostCSS pipeline transforms it instead.
     css: {
       ...vite.css,
-      transformer: 'lightningcss',
+      transformer: lightningcss ? 'lightningcss' : 'postcss',
     },
 
     build: {
       ...vite.build,
 
+      // Vite's only CSS minifier is Lightning CSS itself, so without its
+      // bindings the CSS is left as PostCSS produced it.
+      ...(lightningcss ? {} : { cssMinify: false }),
+
       // Both builds are complete Vite outputs. The server library goes to a
       // private directory; the client writes into the final site.
       outDir,
diff --git a/packages/react/src/html/bundlers/wasm-fallback.mjs b/packages/react/src/html/bundlers/wasm-fallback.mjs
deleted file mode 100644
index 3a8288482..000000000
--- a/packages/react/src/html/bundlers/wasm-fallback.mjs
+++ /dev/null
@@ -1,17 +0,0 @@
-import { registerHooks } from 'node:module';
-
-if (process.arch === 'ppc64' || process.arch === 's390x') {
-  const url = import.meta.resolve('lightningcss-wasm');
-
-  registerHooks({
-    /**
-     * Resolves `lightningcss` to `lightningcss-wasm`.
-     *
-     * @type {import('node:module').ResolveHookSync}
-     */
-    resolve: (specifier, context, nextResolve) =>
-      specifier === 'lightningcss'
-        ? { url, format: 'module', shortCircuit: true }
-        : nextResolve(specifier, context),
-  });
-}
diff --git a/pnpm-lock.yaml b/pnpm-lock.yaml
index 4929c8a15..e32ba2a34 100644
--- a/pnpm-lock.yaml
+++ b/pnpm-lock.yaml
@@ -259,9 +259,6 @@ importers:
       hastscript:
         specifier: ^9.0.1
         version: 9.0.1
-      lightningcss-wasm:
-        specifier: ^1.33.0
-        version: 1.33.0
       mdast-util-slice-markdown:
         specifier: ^2.0.1
         version: 2.0.1
@@ -2509,12 +2506,6 @@ packages:
     os: [linux]
     libc: [musl]
 
-  lightningcss-wasm@1.33.0:
-    resolution: {integrity: sha512-OLAtqEyInBSVWjPrTjpLzcZUMUHO0q+2PFBXKr86nxZOu0P38givj/ZMtRaZ0d38pMTb9wQx+LtaLtHclv+sEA==}
-    engines: {node: '>= 12.0.0'}
-    bundledDependencies:
-      - napi-wasm
-
   lightningcss-win32-arm64-msvc@1.33.0:
     resolution: {integrity: sha512-1K+MPfLSFVpphzpdbfkhlWk6wBrTObBzS2T6db10PNOZgR9GoVsAWzwNyuhUYYbTp23j+4RrncfujZ4uAzXvwA==}
     engines: {node: '>= 12.0.0'}
@@ -5422,8 +5413,6 @@ snapshots:
   lightningcss-linux-x64-musl@1.33.0:
     optional: true
 
-  lightningcss-wasm@1.33.0: {}
-
   lightningcss-win32-arm64-msvc@1.33.0:
     optional: true