diff --git a/src/closure-externs/closure-externs.js b/src/closure-externs/closure-externs.js
index 54484b15cca31..20f1126daa77d 100644
--- a/src/closure-externs/closure-externs.js
+++ b/src/closure-externs/closure-externs.js
@@ -214,3 +214,8 @@ ArrayBuffer.prototype.resizable;
 
 /** @type {boolean} */
 SharedArrayBuffer.prototype.growable;
+
+/**
+ * @return {!ReadableStream}
+ */
+Blob.prototype.stream = function() {};
diff --git a/src/closure-externs/node-externs.js b/src/closure-externs/node-externs.js
index 35c1d058dc19a..30cf9f0099a40 100644
--- a/src/closure-externs/node-externs.js
+++ b/src/closure-externs/node-externs.js
@@ -131,6 +131,14 @@ fs.Stats.prototype.ctimeMs;
  */
 fs.Stats.prototype.blksize;
 
+/**
+ * @param {string|!Buffer|!URL} path
+ * @param {{type: (string|undefined)}=} options
+ * @return {!Promise<!Blob>}
+ * @nosideeffects
+ */
+fs.openAsBlob = function (path, options) {};
+
 /**
  * @param {string} p
  * @return {boolean}
diff --git a/src/postamble_minimal.js b/src/postamble_minimal.js
index a721f98a42259..7033a7a15c11b 100644
--- a/src/postamble_minimal.js
+++ b/src/postamble_minimal.js
@@ -107,7 +107,7 @@ function run() {
 #else
   // Run a persistent (never-exiting) application starting at main().
   _main({{{ argc_argv() }}});
-#endif 
+#endif
 
 #if STACK_OVERFLOW_CHECK
   checkStackCookie();
@@ -189,10 +189,13 @@ var imports = {
 {{{
 #if EXPORT_ES6 && !ENVIRONMENT_MAY_BE_AUDIO_WORKLET
 const moduleUrl = `new URL('${TARGET_BASENAME}.wasm', import.meta.url)`;
+const nodeWasmPath = `require('node:url').fileURLToPath(${moduleUrl})`;
 #elif !EXPORT_ES6 || AUDIO_WORKLET
 const moduleUrl = `'${TARGET_BASENAME}.wasm'`;
+const nodeWasmPath = `__dirname + '/${TARGET_BASENAME}.wasm'`;
 #else
 const moduleUrl = `ENVIRONMENT_IS_AUDIO_WORKLET ? '${TARGET_BASENAME}.wasm' : new URL('${TARGET_BASENAME}.wasm', import.meta.url)`;
+const nodeWasmPath = `__dirname + '/${TARGET_BASENAME}.wasm'`;
 #endif
 }}}
 // https://caniuse.com/#feat=wasm and https://developer.mozilla.org/en-US/docs/Web/JavaScript/Reference/Global_Objects/WebAssembly/instantiateStreaming
@@ -206,13 +209,18 @@ assert(WebAssembly.instantiateStreaming || Module['wasm'], 'Must load WebAssembl
 instantiatePromise =
 #endif
 (WebAssembly.instantiateStreaming
-#if ENVIRONMENT_MAY_BE_NODE
-  // Avoid using instantiateStreaming() on Node.js since the `fetch()` API
-  // does not support `file://` URLs.
-  // See: https://github.com/emscripten-core/emscripten/pull/16917
-  && !ENVIRONMENT_IS_NODE
-#endif
-  ? WebAssembly.instantiateStreaming(fetch({{{ moduleUrl }}}), imports)
+  ? (ENVIRONMENT_IS_NODE
+      // Avoid using `fetch()` API on Node.js since it does not support `file://`
+      // URLs. Instead, provide a Response that wraps a blob with the correct
+      // MIME type.
+      // See: https://github.com/emscripten-core/emscripten/pull/16917
+      ? WebAssembly.instantiateStreaming(
+          require('node:fs')
+            .openAsBlob({{{ nodeWasmPath }}})
+            .then((blob) => new Response(blob.stream(), { headers: { 'Content-Type': 'application/wasm' } })),
+          imports,
+        )
+      : WebAssembly.instantiateStreaming(fetch({{{ moduleUrl }}}), imports))
   : WebAssembly.instantiate(Module['wasm'], imports)).then((output) => {
 #else
 #if MODULARIZE || AUDIO_WORKLET
diff --git a/src/preamble.js b/src/preamble.js
index 54b537db5e8cc..84b53facded61 100644
--- a/src/preamble.js
+++ b/src/preamble.js
@@ -708,9 +708,8 @@ async function instantiateAsync(binary, binaryFile, imports) {
       && !isFileURI(binaryFile)
 #endif
 #if ENVIRONMENT_MAY_BE_NODE
-      // Avoid using instantiateStreaming() on Node.js since the `fetch()` API
-      // does not support `file://` URLs.
-      // See: https://github.com/emscripten-core/emscripten/pull/16917
+      // Node.js is handled in its own branch below, since it can't use fetch()
+      // to stream a `file://` URL
       && !ENVIRONMENT_IS_NODE
 #endif
 #if ENVIRONMENT_MAY_BE_SHELL
@@ -730,6 +729,30 @@ async function instantiateAsync(binary, binaryFile, imports) {
       // fall back of instantiateArrayBuffer below
     };
   }
+#if ENVIRONMENT_MAY_BE_NODE
+  else if (!binary && ENVIRONMENT_IS_NODE) {
+    // Avoid using `fetch()` API on Node.js since it does not support `file://`
+    // URLs. Instead, provide a Response that wraps a fs read stream with the
+    // correct MIME type.
+    // See: https://github.com/emscripten-core/emscripten/pull/16917
+    try {
+      var url = require('node:url');
+      var nodeBinaryFile = isFileURI(binaryFile) ? url.fileURLToPath(binaryFile) : binaryFile;
+      var response = fs.openAsBlob(nodeBinaryFile).then(
+        (blob) =>
+          new Response(blob.stream(), {
+            headers: { 'Content-Type': 'application/wasm' },
+          }),
+      );
+      var instantiationResult = await WebAssembly.instantiateStreaming(response, imports);
+      return instantiationResult;
+    } catch (reason) {
+      err(`wasm streaming compile failed: ${reason}`);
+      err('falling back to ArrayBuffer instantiation');
+      // fall back of instantiateArrayBuffer below
+    };
+  }
+#endif
 #endif // !SINGLE_FILE
   return instantiateArrayBuffer(binaryFile, imports);
 }
diff --git a/test/codesize/test_codesize_cxx_ctors1.json b/test/codesize/test_codesize_cxx_ctors1.json
index ef85ddc7054d5..536f31b502053 100644
--- a/test/codesize/test_codesize_cxx_ctors1.json
+++ b/test/codesize/test_codesize_cxx_ctors1.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 19224,
-  "a.out.js.gz": 8124,
+  "a.out.js": 19546,
+  "a.out.js.gz": 8232,
   "a.out.nodebug.wasm": 133971,
   "a.out.nodebug.wasm.gz": 51271,
-  "total": 153195,
-  "total_gz": 59395,
+  "total": 153517,
+  "total_gz": 59503,
   "sent": [
     "__cxa_throw",
     "_abort_js",
diff --git a/test/codesize/test_codesize_cxx_ctors2.json b/test/codesize/test_codesize_cxx_ctors2.json
index 9745a6316785d..d6256808f4015 100644
--- a/test/codesize/test_codesize_cxx_ctors2.json
+++ b/test/codesize/test_codesize_cxx_ctors2.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 19201,
-  "a.out.js.gz": 8107,
+  "a.out.js": 19523,
+  "a.out.js.gz": 8215,
   "a.out.nodebug.wasm": 133403,
   "a.out.nodebug.wasm.gz": 50959,
-  "total": 152604,
-  "total_gz": 59066,
+  "total": 152926,
+  "total_gz": 59174,
   "sent": [
     "__cxa_throw",
     "_abort_js",
diff --git a/test/codesize/test_codesize_cxx_except.json b/test/codesize/test_codesize_cxx_except.json
index 8e083d22ec62b..20cfd3e84d81c 100644
--- a/test/codesize/test_codesize_cxx_except.json
+++ b/test/codesize/test_codesize_cxx_except.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 22917,
-  "a.out.js.gz": 9082,
+  "a.out.js": 23238,
+  "a.out.js.gz": 9194,
   "a.out.nodebug.wasm": 176383,
   "a.out.nodebug.wasm.gz": 58776,
-  "total": 199300,
-  "total_gz": 67858,
+  "total": 199621,
+  "total_gz": 67970,
   "sent": [
     "__cxa_begin_catch",
     "__cxa_end_catch",
diff --git a/test/codesize/test_codesize_cxx_except_wasm.json b/test/codesize/test_codesize_cxx_except_wasm.json
index acce5eb08a6f9..8959a9ee486fb 100644
--- a/test/codesize/test_codesize_cxx_except_wasm.json
+++ b/test/codesize/test_codesize_cxx_except_wasm.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 19023,
-  "a.out.js.gz": 8039,
+  "a.out.js": 19345,
+  "a.out.js.gz": 8151,
   "a.out.nodebug.wasm": 149640,
   "a.out.nodebug.wasm.gz": 56311,
-  "total": 168663,
-  "total_gz": 64350,
+  "total": 168985,
+  "total_gz": 64462,
   "sent": [
     "_abort_js",
     "_tzset_js",
diff --git a/test/codesize/test_codesize_cxx_except_wasm_legacy.json b/test/codesize/test_codesize_cxx_except_wasm_legacy.json
index 7d2e3ac6023e4..a0bdc5ed08a98 100644
--- a/test/codesize/test_codesize_cxx_except_wasm_legacy.json
+++ b/test/codesize/test_codesize_cxx_except_wasm_legacy.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 19101,
-  "a.out.js.gz": 8065,
+  "a.out.js": 19423,
+  "a.out.js.gz": 8174,
   "a.out.nodebug.wasm": 147422,
   "a.out.nodebug.wasm.gz": 55982,
-  "total": 166523,
-  "total_gz": 64047,
+  "total": 166845,
+  "total_gz": 64156,
   "sent": [
     "_abort_js",
     "_tzset_js",
diff --git a/test/codesize/test_codesize_cxx_lto.json b/test/codesize/test_codesize_cxx_lto.json
index 5bf114b165af0..ee0d9a34b1358 100644
--- a/test/codesize/test_codesize_cxx_lto.json
+++ b/test/codesize/test_codesize_cxx_lto.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 18568,
-  "a.out.js.gz": 7818,
+  "a.out.js": 18890,
+  "a.out.js.gz": 7931,
   "a.out.nodebug.wasm": 101064,
   "a.out.nodebug.wasm.gz": 38292,
-  "total": 119632,
-  "total_gz": 46110,
+  "total": 119954,
+  "total_gz": 46223,
   "sent": [
     "a (emscripten_resize_heap)",
     "b (_setitimer_js)",
diff --git a/test/codesize/test_codesize_cxx_mangle.json b/test/codesize/test_codesize_cxx_mangle.json
index a9df7ddb5796f..545ac3d1d0e2e 100644
--- a/test/codesize/test_codesize_cxx_mangle.json
+++ b/test/codesize/test_codesize_cxx_mangle.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 22967,
-  "a.out.js.gz": 9103,
+  "a.out.js": 23288,
+  "a.out.js.gz": 9214,
   "a.out.nodebug.wasm": 242663,
   "a.out.nodebug.wasm.gz": 81001,
-  "total": 265630,
-  "total_gz": 90104,
+  "total": 265951,
+  "total_gz": 90215,
   "sent": [
     "__cxa_begin_catch",
     "__cxa_end_catch",
diff --git a/test/codesize/test_codesize_cxx_noexcept.json b/test/codesize/test_codesize_cxx_noexcept.json
index 608a59b681293..6988c47d39d40 100644
--- a/test/codesize/test_codesize_cxx_noexcept.json
+++ b/test/codesize/test_codesize_cxx_noexcept.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 19224,
-  "a.out.js.gz": 8124,
+  "a.out.js": 19546,
+  "a.out.js.gz": 8232,
   "a.out.nodebug.wasm": 135882,
   "a.out.nodebug.wasm.gz": 51885,
-  "total": 155106,
-  "total_gz": 60009,
+  "total": 155428,
+  "total_gz": 60117,
   "sent": [
     "__cxa_throw",
     "_abort_js",
diff --git a/test/codesize/test_codesize_cxx_wasmfs.json b/test/codesize/test_codesize_cxx_wasmfs.json
index a50f193ba380b..2af66e642002b 100644
--- a/test/codesize/test_codesize_cxx_wasmfs.json
+++ b/test/codesize/test_codesize_cxx_wasmfs.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 6604,
-  "a.out.js.gz": 3154,
+  "a.out.js": 6926,
+  "a.out.js.gz": 3270,
   "a.out.nodebug.wasm": 173607,
   "a.out.nodebug.wasm.gz": 64636,
-  "total": 180211,
-  "total_gz": 67790,
+  "total": 180533,
+  "total_gz": 67906,
   "sent": [
     "__cxa_throw",
     "_abort_js",
diff --git a/test/codesize/test_codesize_file_preload.expected.js b/test/codesize/test_codesize_file_preload.expected.js
index 6999515586248..a2d2f87a194db 100644
--- a/test/codesize/test_codesize_file_preload.expected.js
+++ b/test/codesize/test_codesize_file_preload.expected.js
@@ -428,6 +428,25 @@ async function instantiateAsync(binary, binaryFile, imports) {
       err(`wasm streaming compile failed: ${reason}`);
       err("falling back to ArrayBuffer instantiation");
     }
+  } else if (!binary && ENVIRONMENT_IS_NODE) {
+    // Avoid using `fetch()` API on Node.js since it does not support `file://`
+    // URLs. Instead, provide a Response that wraps a fs read stream with the
+    // correct MIME type.
+    // See: https://github.com/emscripten-core/emscripten/pull/16917
+    try {
+      var url = require("node:url");
+      var nodeBinaryFile = isFileURI(binaryFile) ? url.fileURLToPath(binaryFile) : binaryFile;
+      var response = fs.openAsBlob(nodeBinaryFile).then(blob => new Response(blob.stream(), {
+        headers: {
+          "Content-Type": "application/wasm"
+        }
+      }));
+      var instantiationResult = await WebAssembly.instantiateStreaming(response, imports);
+      return instantiationResult;
+    } catch (reason) {
+      err(`wasm streaming compile failed: ${reason}`);
+      err("falling back to ArrayBuffer instantiation");
+    }
   }
   return instantiateArrayBuffer(binaryFile, imports);
 }
diff --git a/test/codesize/test_codesize_file_preload.json b/test/codesize/test_codesize_file_preload.json
index 8a288445877b2..ed326d938c155 100644
--- a/test/codesize/test_codesize_file_preload.json
+++ b/test/codesize/test_codesize_file_preload.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 22203,
-  "a.out.js.gz": 9267,
+  "a.out.js": 22525,
+  "a.out.js.gz": 9372,
   "a.out.nodebug.wasm": 1198,
   "a.out.nodebug.wasm.gz": 730,
-  "total": 23401,
-  "total_gz": 9997,
+  "total": 23723,
+  "total_gz": 10102,
   "sent": [
     "a (fd_write)"
   ],
diff --git a/test/codesize/test_codesize_files_js_fs.json b/test/codesize/test_codesize_files_js_fs.json
index 0c033a7242071..3317f62590734 100644
--- a/test/codesize/test_codesize_files_js_fs.json
+++ b/test/codesize/test_codesize_files_js_fs.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 17871,
-  "a.out.js.gz": 7460,
+  "a.out.js": 18193,
+  "a.out.js.gz": 7575,
   "a.out.nodebug.wasm": 381,
   "a.out.nodebug.wasm.gz": 258,
-  "total": 18252,
-  "total_gz": 7718,
+  "total": 18574,
+  "total_gz": 7833,
   "sent": [
     "a (fd_write)",
     "b (fd_read)",
diff --git a/test/codesize/test_codesize_files_wasmfs.json b/test/codesize/test_codesize_files_wasmfs.json
index 5326a3c193b07..cd7fb05aadf75 100644
--- a/test/codesize/test_codesize_files_wasmfs.json
+++ b/test/codesize/test_codesize_files_wasmfs.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 4979,
-  "a.out.js.gz": 2409,
+  "a.out.js": 5301,
+  "a.out.js.gz": 2523,
   "a.out.nodebug.wasm": 58252,
   "a.out.nodebug.wasm.gz": 18292,
-  "total": 63231,
-  "total_gz": 20701,
+  "total": 63553,
+  "total_gz": 20815,
   "sent": [
     "a (emscripten_date_now)",
     "b (emscripten_err)",
diff --git a/test/codesize/test_codesize_hello_O0.json b/test/codesize/test_codesize_hello_O0.json
index 0a131354a605f..8aacacc638840 100644
--- a/test/codesize/test_codesize_hello_O0.json
+++ b/test/codesize/test_codesize_hello_O0.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 23596,
-  "a.out.js.gz": 8582,
+  "a.out.js": 23995,
+  "a.out.js.gz": 8698,
   "a.out.nodebug.wasm": 14279,
   "a.out.nodebug.wasm.gz": 7101,
-  "total": 37875,
-  "total_gz": 15683,
+  "total": 38274,
+  "total_gz": 15799,
   "sent": [
     "fd_write"
   ],
diff --git a/test/codesize/test_codesize_hello_O1.json b/test/codesize/test_codesize_hello_O1.json
index e0f7a25ea23c8..78b35ab452bb9 100644
--- a/test/codesize/test_codesize_hello_O1.json
+++ b/test/codesize/test_codesize_hello_O1.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 5516,
-  "a.out.js.gz": 2242,
+  "a.out.js": 5915,
+  "a.out.js.gz": 2366,
   "a.out.nodebug.wasm": 2050,
   "a.out.nodebug.wasm.gz": 1231,
-  "total": 7566,
-  "total_gz": 3473,
+  "total": 7965,
+  "total_gz": 3597,
   "sent": [
     "fd_write"
   ],
diff --git a/test/codesize/test_codesize_hello_O2.json b/test/codesize/test_codesize_hello_O2.json
index 5cc957a275f08..30e76b1f37351 100644
--- a/test/codesize/test_codesize_hello_O2.json
+++ b/test/codesize/test_codesize_hello_O2.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3855,
-  "a.out.js.gz": 1966,
+  "a.out.js": 4176,
+  "a.out.js.gz": 2078,
   "a.out.nodebug.wasm": 1444,
   "a.out.nodebug.wasm.gz": 922,
-  "total": 5299,
-  "total_gz": 2888,
+  "total": 5620,
+  "total_gz": 3000,
   "sent": [
     "fd_write"
   ],
diff --git a/test/codesize/test_codesize_hello_O3.json b/test/codesize/test_codesize_hello_O3.json
index 832365a8f1c6b..75778b81fe942 100644
--- a/test/codesize/test_codesize_hello_O3.json
+++ b/test/codesize/test_codesize_hello_O3.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3797,
-  "a.out.js.gz": 1925,
+  "a.out.js": 4118,
+  "a.out.js.gz": 2036,
   "a.out.nodebug.wasm": 1198,
   "a.out.nodebug.wasm.gz": 730,
-  "total": 4995,
-  "total_gz": 2655,
+  "total": 5316,
+  "total_gz": 2766,
   "sent": [
     "a (fd_write)"
   ],
diff --git a/test/codesize/test_codesize_hello_Os.json b/test/codesize/test_codesize_hello_Os.json
index 55e52acdc3ab6..7c5848683838b 100644
--- a/test/codesize/test_codesize_hello_Os.json
+++ b/test/codesize/test_codesize_hello_Os.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3797,
-  "a.out.js.gz": 1925,
+  "a.out.js": 4118,
+  "a.out.js.gz": 2036,
   "a.out.nodebug.wasm": 1188,
   "a.out.nodebug.wasm.gz": 732,
-  "total": 4985,
-  "total_gz": 2657,
+  "total": 5306,
+  "total_gz": 2768,
   "sent": [
     "a (fd_write)"
   ],
diff --git a/test/codesize/test_codesize_hello_Oz.json b/test/codesize/test_codesize_hello_Oz.json
index 1739d3afc7aaf..e73679e7a4985 100644
--- a/test/codesize/test_codesize_hello_Oz.json
+++ b/test/codesize/test_codesize_hello_Oz.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3434,
-  "a.out.js.gz": 1729,
+  "a.out.js": 3756,
+  "a.out.js.gz": 1842,
   "a.out.nodebug.wasm": 1188,
   "a.out.nodebug.wasm.gz": 732,
-  "total": 4622,
-  "total_gz": 2461,
+  "total": 4944,
+  "total_gz": 2574,
   "sent": [
     "a (fd_write)"
   ],
diff --git a/test/codesize/test_codesize_hello_dylink.json b/test/codesize/test_codesize_hello_dylink.json
index 27c28e6b09a79..de302b2298d9e 100644
--- a/test/codesize/test_codesize_hello_dylink.json
+++ b/test/codesize/test_codesize_hello_dylink.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 26188,
-  "a.out.js.gz": 11168,
+  "a.out.js": 26511,
+  "a.out.js.gz": 11289,
   "a.out.nodebug.wasm": 16992,
   "a.out.nodebug.wasm.gz": 8679,
-  "total": 43180,
-  "total_gz": 19847,
+  "total": 43503,
+  "total_gz": 19968,
   "sent": [
     "__syscall_stat64",
     "emscripten_resize_heap",
diff --git a/test/codesize/test_codesize_hello_dylink_all.json b/test/codesize/test_codesize_hello_dylink_all.json
index 2599da95e6573..1fa53754171a1 100644
--- a/test/codesize/test_codesize_hello_dylink_all.json
+++ b/test/codesize/test_codesize_hello_dylink_all.json
@@ -1,7 +1,7 @@
 {
-  "a.out.js": 270695,
+  "a.out.js": 271019,
   "a.out.nodebug.wasm": 588289,
-  "total": 858984,
+  "total": 859308,
   "sent": [
     "IMG_Init",
     "IMG_Load",
diff --git a/test/codesize/test_codesize_hello_export_nothing.json b/test/codesize/test_codesize_hello_export_nothing.json
index c4012b3373c4f..d8fd623e58cc8 100644
--- a/test/codesize/test_codesize_hello_export_nothing.json
+++ b/test/codesize/test_codesize_hello_export_nothing.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 2642,
-  "a.out.js.gz": 1290,
+  "a.out.js": 2964,
+  "a.out.js.gz": 1404,
   "a.out.nodebug.wasm": 43,
   "a.out.nodebug.wasm.gz": 59,
-  "total": 2685,
-  "total_gz": 1349,
+  "total": 3007,
+  "total_gz": 1463,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_hello_wasmfs.json b/test/codesize/test_codesize_hello_wasmfs.json
index 832365a8f1c6b..75778b81fe942 100644
--- a/test/codesize/test_codesize_hello_wasmfs.json
+++ b/test/codesize/test_codesize_hello_wasmfs.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3797,
-  "a.out.js.gz": 1925,
+  "a.out.js": 4118,
+  "a.out.js.gz": 2036,
   "a.out.nodebug.wasm": 1198,
   "a.out.nodebug.wasm.gz": 730,
-  "total": 4995,
-  "total_gz": 2655,
+  "total": 5316,
+  "total_gz": 2766,
   "sent": [
     "a (fd_write)"
   ],
diff --git a/test/codesize/test_codesize_libcxxabi_message_O3.json b/test/codesize/test_codesize_libcxxabi_message_O3.json
index a3d564f5f2563..ce50074a8c1e1 100644
--- a/test/codesize/test_codesize_libcxxabi_message_O3.json
+++ b/test/codesize/test_codesize_libcxxabi_message_O3.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3010,
-  "a.out.js.gz": 1480,
+  "a.out.js": 3331,
+  "a.out.js.gz": 1591,
   "a.out.nodebug.wasm": 89,
   "a.out.nodebug.wasm.gz": 98,
-  "total": 3099,
-  "total_gz": 1578,
+  "total": 3420,
+  "total_gz": 1689,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_libcxxabi_message_O3_standalone.json b/test/codesize/test_codesize_libcxxabi_message_O3_standalone.json
index 2cc7597db55ab..d25a95beeb928 100644
--- a/test/codesize/test_codesize_libcxxabi_message_O3_standalone.json
+++ b/test/codesize/test_codesize_libcxxabi_message_O3_standalone.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3093,
-  "a.out.js.gz": 1530,
+  "a.out.js": 3415,
+  "a.out.js.gz": 1648,
   "a.out.nodebug.wasm": 222,
   "a.out.nodebug.wasm.gz": 206,
-  "total": 3315,
-  "total_gz": 1736,
+  "total": 3637,
+  "total_gz": 1854,
   "sent": [
     "proc_exit"
   ],
diff --git a/test/codesize/test_codesize_mem_O3.json b/test/codesize/test_codesize_mem_O3.json
index 886be4087c960..4ef3ea96eca4d 100644
--- a/test/codesize/test_codesize_mem_O3.json
+++ b/test/codesize/test_codesize_mem_O3.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3875,
-  "a.out.js.gz": 1925,
+  "a.out.js": 4196,
+  "a.out.js.gz": 2038,
   "a.out.nodebug.wasm": 5268,
   "a.out.nodebug.wasm.gz": 2433,
-  "total": 9143,
-  "total_gz": 4358,
+  "total": 9464,
+  "total_gz": 4471,
   "sent": [
     "a (emscripten_resize_heap)"
   ],
diff --git a/test/codesize/test_codesize_mem_O3_grow.json b/test/codesize/test_codesize_mem_O3_grow.json
index 425b77043764f..b82aa14f6886b 100644
--- a/test/codesize/test_codesize_mem_O3_grow.json
+++ b/test/codesize/test_codesize_mem_O3_grow.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 4209,
-  "a.out.js.gz": 2101,
+  "a.out.js": 4531,
+  "a.out.js.gz": 2214,
   "a.out.nodebug.wasm": 5269,
   "a.out.nodebug.wasm.gz": 2433,
-  "total": 9478,
-  "total_gz": 4534,
+  "total": 9800,
+  "total_gz": 4647,
   "sent": [
     "a (emscripten_resize_heap)"
   ],
diff --git a/test/codesize/test_codesize_mem_O3_grow_standalone.json b/test/codesize/test_codesize_mem_O3_grow_standalone.json
index bbf629f321167..0f5433d8b37d1 100644
--- a/test/codesize/test_codesize_mem_O3_grow_standalone.json
+++ b/test/codesize/test_codesize_mem_O3_grow_standalone.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3657,
-  "a.out.js.gz": 1834,
+  "a.out.js": 3979,
+  "a.out.js.gz": 1945,
   "a.out.nodebug.wasm": 5649,
   "a.out.nodebug.wasm.gz": 2669,
-  "total": 9306,
-  "total_gz": 4503,
+  "total": 9628,
+  "total_gz": 4614,
   "sent": [
     "args_get",
     "args_sizes_get",
diff --git a/test/codesize/test_codesize_mem_O3_standalone.json b/test/codesize/test_codesize_mem_O3_standalone.json
index 61f177858fad1..507f6e1ec4671 100644
--- a/test/codesize/test_codesize_mem_O3_standalone.json
+++ b/test/codesize/test_codesize_mem_O3_standalone.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3567,
-  "a.out.js.gz": 1784,
+  "a.out.js": 3889,
+  "a.out.js.gz": 1898,
   "a.out.nodebug.wasm": 5573,
   "a.out.nodebug.wasm.gz": 2608,
-  "total": 9140,
-  "total_gz": 4392,
+  "total": 9462,
+  "total_gz": 4506,
   "sent": [
     "args_get",
     "args_sizes_get",
diff --git a/test/codesize/test_codesize_mem_O3_standalone_lib.json b/test/codesize/test_codesize_mem_O3_standalone_lib.json
index c12751084994c..1da1e504666bc 100644
--- a/test/codesize/test_codesize_mem_O3_standalone_lib.json
+++ b/test/codesize/test_codesize_mem_O3_standalone_lib.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3086,
-  "a.out.js.gz": 1523,
+  "a.out.js": 3408,
+  "a.out.js.gz": 1637,
   "a.out.nodebug.wasm": 5248,
   "a.out.nodebug.wasm.gz": 2368,
-  "total": 8334,
-  "total_gz": 3891,
+  "total": 8656,
+  "total_gz": 4005,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_mem_O3_standalone_narg.json b/test/codesize/test_codesize_mem_O3_standalone_narg.json
index 34167a05ea85c..78c558d46ec36 100644
--- a/test/codesize/test_codesize_mem_O3_standalone_narg.json
+++ b/test/codesize/test_codesize_mem_O3_standalone_narg.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3093,
-  "a.out.js.gz": 1530,
+  "a.out.js": 3415,
+  "a.out.js.gz": 1648,
   "a.out.nodebug.wasm": 5362,
   "a.out.nodebug.wasm.gz": 2451,
-  "total": 8455,
-  "total_gz": 3981,
+  "total": 8777,
+  "total_gz": 4099,
   "sent": [
     "proc_exit"
   ],
diff --git a/test/codesize/test_codesize_mem_O3_standalone_narg_flto.json b/test/codesize/test_codesize_mem_O3_standalone_narg_flto.json
index d1c92228a1005..803ccbeb139ac 100644
--- a/test/codesize/test_codesize_mem_O3_standalone_narg_flto.json
+++ b/test/codesize/test_codesize_mem_O3_standalone_narg_flto.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 3093,
-  "a.out.js.gz": 1530,
+  "a.out.js": 3415,
+  "a.out.js.gz": 1648,
   "a.out.nodebug.wasm": 4293,
   "a.out.nodebug.wasm.gz": 2147,
-  "total": 7386,
-  "total_gz": 3677,
+  "total": 7708,
+  "total_gz": 3795,
   "sent": [
     "proc_exit"
   ],
diff --git a/test/codesize/test_codesize_minimal_64.json b/test/codesize/test_codesize_minimal_64.json
index 22e523cfc996e..d83b72d54d316 100644
--- a/test/codesize/test_codesize_minimal_64.json
+++ b/test/codesize/test_codesize_minimal_64.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 2364,
-  "a.out.js.gz": 1155,
+  "a.out.js": 2685,
+  "a.out.js.gz": 1267,
   "a.out.nodebug.wasm": 75,
   "a.out.nodebug.wasm.gz": 88,
-  "total": 2439,
-  "total_gz": 1243,
+  "total": 2760,
+  "total_gz": 1355,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_minimal_O0.expected.js b/test/codesize/test_codesize_minimal_O0.expected.js
index 61b5952de1fd0..d09fbd9b8b270 100644
--- a/test/codesize/test_codesize_minimal_O0.expected.js
+++ b/test/codesize/test_codesize_minimal_O0.expected.js
@@ -651,9 +651,8 @@ async function instantiateAsync(binary, binaryFile, imports) {
   if (!binary
       // Don't use streaming for file:// delivered objects in a webview, fetch them synchronously.
       && !isFileURI(binaryFile)
-      // Avoid using instantiateStreaming() on Node.js since the `fetch()` API
-      // does not support `file://` URLs.
-      // See: https://github.com/emscripten-core/emscripten/pull/16917
+      // Node.js is handled in its own branch below, since it can't use fetch()
+      // to stream a `file://` URL
       && !ENVIRONMENT_IS_NODE
      ) {
     try {
@@ -668,6 +667,28 @@ async function instantiateAsync(binary, binaryFile, imports) {
       // fall back of instantiateArrayBuffer below
     };
   }
+  else if (!binary && ENVIRONMENT_IS_NODE) {
+    // Avoid using `fetch()` API on Node.js since it does not support `file://`
+    // URLs. Instead, provide a Response that wraps a fs read stream with the
+    // correct MIME type.
+    // See: https://github.com/emscripten-core/emscripten/pull/16917
+    try {
+      var url = require('node:url');
+      var nodeBinaryFile = isFileURI(binaryFile) ? url.fileURLToPath(binaryFile) : binaryFile;
+      var response = fs.openAsBlob(nodeBinaryFile).then(
+        (blob) =>
+          new Response(blob.stream(), {
+            headers: { 'Content-Type': 'application/wasm' },
+          }),
+      );
+      var instantiationResult = await WebAssembly.instantiateStreaming(response, imports);
+      return instantiationResult;
+    } catch (reason) {
+      err(`wasm streaming compile failed: ${reason}`);
+      err('falling back to ArrayBuffer instantiation');
+      // fall back of instantiateArrayBuffer below
+    };
+  }
   return instantiateArrayBuffer(binaryFile, imports);
 }
 
diff --git a/test/codesize/test_codesize_minimal_O0.json b/test/codesize/test_codesize_minimal_O0.json
index f960557acfdd1..047d4d2550008 100644
--- a/test/codesize/test_codesize_minimal_O0.json
+++ b/test/codesize/test_codesize_minimal_O0.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 18801,
-  "a.out.js.gz": 6758,
+  "a.out.js": 19200,
+  "a.out.js.gz": 6879,
   "a.out.nodebug.wasm": 1071,
   "a.out.nodebug.wasm.gz": 636,
-  "total": 19872,
-  "total_gz": 7394,
+  "total": 20271,
+  "total_gz": 7515,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_minimal_O1.json b/test/codesize/test_codesize_minimal_O1.json
index 19ff15d14dac8..6bd0957a3902d 100644
--- a/test/codesize/test_codesize_minimal_O1.json
+++ b/test/codesize/test_codesize_minimal_O1.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 2670,
-  "a.out.js.gz": 1167,
+  "a.out.js": 3069,
+  "a.out.js.gz": 1290,
   "a.out.nodebug.wasm": 505,
   "a.out.nodebug.wasm.gz": 378,
-  "total": 3175,
-  "total_gz": 1545,
+  "total": 3574,
+  "total_gz": 1668,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_minimal_O2.json b/test/codesize/test_codesize_minimal_O2.json
index bd4d07eef5864..f2fa6d370d5ef 100644
--- a/test/codesize/test_codesize_minimal_O2.json
+++ b/test/codesize/test_codesize_minimal_O2.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 2052,
-  "a.out.js.gz": 1058,
+  "a.out.js": 2374,
+  "a.out.js.gz": 1169,
   "a.out.nodebug.wasm": 326,
   "a.out.nodebug.wasm.gz": 263,
-  "total": 2378,
-  "total_gz": 1321,
+  "total": 2700,
+  "total_gz": 1432,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_minimal_O3.json b/test/codesize/test_codesize_minimal_O3.json
index 5fe4c0860fef6..e329561280605 100644
--- a/test/codesize/test_codesize_minimal_O3.json
+++ b/test/codesize/test_codesize_minimal_O3.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 1998,
-  "a.out.js.gz": 1027,
+  "a.out.js": 2320,
+  "a.out.js.gz": 1137,
   "a.out.nodebug.wasm": 75,
   "a.out.nodebug.wasm.gz": 87,
-  "total": 2073,
-  "total_gz": 1114,
+  "total": 2395,
+  "total_gz": 1224,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_minimal_Os.json b/test/codesize/test_codesize_minimal_Os.json
index 5fe4c0860fef6..e329561280605 100644
--- a/test/codesize/test_codesize_minimal_Os.json
+++ b/test/codesize/test_codesize_minimal_Os.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 1998,
-  "a.out.js.gz": 1027,
+  "a.out.js": 2320,
+  "a.out.js.gz": 1137,
   "a.out.nodebug.wasm": 75,
   "a.out.nodebug.wasm.gz": 87,
-  "total": 2073,
-  "total_gz": 1114,
+  "total": 2395,
+  "total_gz": 1224,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_minimal_Oz-ctors.json b/test/codesize/test_codesize_minimal_Oz-ctors.json
index 01649ef200d36..86694f6d09ae9 100644
--- a/test/codesize/test_codesize_minimal_Oz-ctors.json
+++ b/test/codesize/test_codesize_minimal_Oz-ctors.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 1980,
-  "a.out.js.gz": 1012,
+  "a.out.js": 2302,
+  "a.out.js.gz": 1123,
   "a.out.nodebug.wasm": 64,
   "a.out.nodebug.wasm.gz": 80,
-  "total": 2044,
-  "total_gz": 1092,
+  "total": 2366,
+  "total_gz": 1203,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_minimal_Oz.json b/test/codesize/test_codesize_minimal_Oz.json
index 5fe4c0860fef6..e329561280605 100644
--- a/test/codesize/test_codesize_minimal_Oz.json
+++ b/test/codesize/test_codesize_minimal_Oz.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 1998,
-  "a.out.js.gz": 1027,
+  "a.out.js": 2320,
+  "a.out.js.gz": 1137,
   "a.out.nodebug.wasm": 75,
   "a.out.nodebug.wasm.gz": 87,
-  "total": 2073,
-  "total_gz": 1114,
+  "total": 2395,
+  "total_gz": 1224,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_minimal_esm.json b/test/codesize/test_codesize_minimal_esm.json
index fe01e4510c897..7655c3cfb9c26 100644
--- a/test/codesize/test_codesize_minimal_esm.json
+++ b/test/codesize/test_codesize_minimal_esm.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 2137,
-  "a.out.js.gz": 1050,
+  "a.out.js": 2451,
+  "a.out.js.gz": 1152,
   "a.out.nodebug.wasm": 75,
   "a.out.nodebug.wasm.gz": 87,
-  "total": 2212,
-  "total_gz": 1137,
+  "total": 2526,
+  "total_gz": 1239,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_codesize_minimal_pthreads.json b/test/codesize/test_codesize_minimal_pthreads.json
index f897ee3214106..0b3cc7a28e3c1 100644
--- a/test/codesize/test_codesize_minimal_pthreads.json
+++ b/test/codesize/test_codesize_minimal_pthreads.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 6900,
-  "a.out.js.gz": 3432,
+  "a.out.js": 7222,
+  "a.out.js.gz": 3546,
   "a.out.nodebug.wasm": 19147,
   "a.out.nodebug.wasm.gz": 8834,
-  "total": 26047,
-  "total_gz": 12266,
+  "total": 26369,
+  "total_gz": 12380,
   "sent": [
     "a (memory)",
     "b (exit)",
diff --git a/test/codesize/test_codesize_minimal_pthreads_memgrowth.json b/test/codesize/test_codesize_minimal_pthreads_memgrowth.json
index 5124575dc3ca5..2b837d800b28b 100644
--- a/test/codesize/test_codesize_minimal_pthreads_memgrowth.json
+++ b/test/codesize/test_codesize_minimal_pthreads_memgrowth.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 7358,
-  "a.out.js.gz": 3648,
+  "a.out.js": 7680,
+  "a.out.js.gz": 3763,
   "a.out.nodebug.wasm": 19148,
   "a.out.nodebug.wasm.gz": 8835,
-  "total": 26506,
-  "total_gz": 12483,
+  "total": 26828,
+  "total_gz": 12598,
   "sent": [
     "a (memory)",
     "b (exit)",
diff --git a/test/codesize/test_codesize_minimal_wasmfs.json b/test/codesize/test_codesize_minimal_wasmfs.json
index 5fe4c0860fef6..e329561280605 100644
--- a/test/codesize/test_codesize_minimal_wasmfs.json
+++ b/test/codesize/test_codesize_minimal_wasmfs.json
@@ -1,10 +1,10 @@
 {
-  "a.out.js": 1998,
-  "a.out.js.gz": 1027,
+  "a.out.js": 2320,
+  "a.out.js.gz": 1137,
   "a.out.nodebug.wasm": 75,
   "a.out.nodebug.wasm.gz": 87,
-  "total": 2073,
-  "total_gz": 1114,
+  "total": 2395,
+  "total_gz": 1224,
   "sent": [],
   "imports": [],
   "exports": [
diff --git a/test/codesize/test_unoptimized_code_size.json b/test/codesize/test_unoptimized_code_size.json
index a6bc588a5bc49..b70b6a4ac3fb9 100644
--- a/test/codesize/test_unoptimized_code_size.json
+++ b/test/codesize/test_unoptimized_code_size.json
@@ -1,16 +1,16 @@
 {
-  "hello_world.js": 54705,
-  "hello_world.js.gz": 17355,
+  "hello_world.js": 55588,
+  "hello_world.js.gz": 17582,
   "hello_world.wasm": 14279,
   "hello_world.wasm.gz": 7101,
-  "no_asserts.js": 23596,
-  "no_asserts.js.gz": 8277,
+  "no_asserts.js": 24479,
+  "no_asserts.js.gz": 8497,
   "no_asserts.wasm": 11393,
   "no_asserts.wasm.gz": 5646,
-  "strict.js": 51856,
-  "strict.js.gz": 16348,
+  "strict.js": 52739,
+  "strict.js.gz": 16580,
   "strict.wasm": 14279,
   "strict.wasm.gz": 7098,
-  "total": 170108,
-  "total_gz": 61825
+  "total": 172757,
+  "total_gz": 62504
 }