diff --git a/eng/pipelines/runtime.yml b/eng/pipelines/runtime.yml
index 0ded77757945b9..5cca8c7ca4d443 100644
--- a/eng/pipelines/runtime.yml
+++ b/eng/pipelines/runtime.yml
@@ -1957,6 +1957,32 @@ extends:
                 eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_wasm_coreclr_runtimetests.containsChange'], true),
                 eq(variables['isRollingBuild'], true))
 
+      - template: /eng/pipelines/common/platform-matrix.yml
+        parameters:
+          jobTemplate: /eng/pipelines/common/templates/runtimes/run-test-job.yml
+          buildConfig: checked
+          platforms:
+          - browser_wasm
+          helixQueueGroup: pr
+          helixQueuesTemplate: /eng/pipelines/coreclr/templates/helix-queues-setup.yml
+          jobParameters:
+            testGroup: innerloop
+            readyToRun: true
+            displayNameArgs: R2R_CG2
+            liveLibrariesBuildConfig: Release
+            unifiedArtifactsName: CoreCLR_ReleaseLibraries_BuildArtifacts_$(osGroup)$(osSubgroup)_$(archType)_$(_hostedOs)_$(_BuildConfig)
+            unifiedBuildNameSuffix: CoreCLR_ReleaseLibraries
+            useHelixMonitor: ${{ variables.enableHelixJobMonitor }}
+            extraBuildArgs: -os browser -p:HostConfiguration=Release
+            condition: >-
+              or(
+                eq(variables['wasmDarcDependenciesChanged'], true),
+                eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_coreclr.containsChange'], true),
+                eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_runtimetests.containsChange'], true),
+                eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_tools_illink.containsChange'], true),
+                eq(stageDependencies.EvaluatePaths.evaluate_paths.outputs['SetPathVars_wasm_coreclr_runtimetests.containsChange'], true),
+                eq(variables['isRollingBuild'], true))
+
       - template: /eng/pipelines/common/platform-matrix.yml
         parameters:
           jobTemplate: /eng/pipelines/common/templates/runtimes/run-test-job.yml
diff --git a/src/tests/Common/CLRTest.CrossGen.targets b/src/tests/Common/CLRTest.CrossGen.targets
index cb6199498aa7ea..2307e7ff07b65e 100644
--- a/src/tests/Common/CLRTest.CrossGen.targets
+++ b/src/tests/Common/CLRTest.CrossGen.targets
@@ -60,6 +60,7 @@ fi
 
 # CrossGen2 Script
 if [ ! -z ${RunCrossGen2+x} ]%3B then
+  export TEST_READY_TO_RUN_MODE=1
   compilationDoneFlagFile="IL-CG2/done"
   if [ -d IL-CG2 ]%3B then
     while [ ! -f $compilationDoneFlagFile ]%3B
@@ -277,6 +278,7 @@ if /i "$(AlwaysUseCrossGen2)" == "true" (
 
 REM CrossGen2 Script
 if defined RunCrossGen2 (
+    set TEST_READY_TO_RUN_MODE=1
     set ExtraCrossGen2Args=!ExtraCrossGen2Args! $(CrossGen2TestExtraArguments)
     set CrossGen2TestCheckPdb=$(CrossGen2TestCheckPdb)
     set __CreatePdb=$(__CreatePdb)
diff --git a/src/tests/Common/CoreCLRTestLibrary/PlatformDetection.cs b/src/tests/Common/CoreCLRTestLibrary/PlatformDetection.cs
index 9a8639a1a3aaf0..ca8e5435e69c3b 100644
--- a/src/tests/Common/CoreCLRTestLibrary/PlatformDetection.cs
+++ b/src/tests/Common/CoreCLRTestLibrary/PlatformDetection.cs
@@ -111,6 +111,7 @@ public static bool IsMonoInterpreter
         public static bool IsBrowser => OperatingSystem.IsBrowser();
         public static bool IsWasi => OperatingSystem.IsWasi();
         public static bool IsWasm => IsBrowser || IsWasi;
+        public static bool IsReadyToRunCompiled => Environment.GetEnvironmentVariable("TEST_READY_TO_RUN_MODE") == "1";
         public static bool IsNotMultithreadingSupported => !IsMultithreadingSupported;
         public static bool IsMultithreadingSupported => RuntimeFeature.IsMultithreadingSupported;
 
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_131285/Runtime_131285.csproj b/src/tests/JIT/Regression/JitBlue/Runtime_131285/Runtime_131285.csproj
index 5800912293b6cd..de6d5e08882e86 100644
--- a/src/tests/JIT/Regression/JitBlue/Runtime_131285/Runtime_131285.csproj
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_131285/Runtime_131285.csproj
@@ -1,14 +1,6 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
     <Optimize>True</Optimize>
-    <!-- The bug is wasm R2R (crossgen) codegen. On non-browser legs this runs as
-         ordinary JIT/interp and passes trivially (expected). On the browser leg,
-         AlwaysUseCrossGen2 forces crossgen (exports RunCrossGen2=1) so the test is
-         actually compiled to wasm R2R and run under node; otherwise a plain
-         browser leg runs it as normal JIT and silently false-passes without ever
-         exercising the fix. CrossGen2OutputFormat=wasm is set automatically for
-         TargetOS=browser (src/tests/Directory.Build.props). -->
-    <AlwaysUseCrossGen2 Condition="'$(TargetOS)' == 'browser'">true</AlwaysUseCrossGen2>
   </PropertyGroup>
   <ItemGroup>
     <Compile Include="$(MSBuildProjectName).cs" />
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_131373/Runtime_131373.csproj b/src/tests/JIT/Regression/JitBlue/Runtime_131373/Runtime_131373.csproj
index 4141d0e54db4a7..de6d5e08882e86 100644
--- a/src/tests/JIT/Regression/JitBlue/Runtime_131373/Runtime_131373.csproj
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_131373/Runtime_131373.csproj
@@ -1,8 +1,6 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
     <Optimize>True</Optimize>
-    <!-- Force crossgen on the browser leg so this actually runs as wasm R2R. -->
-    <AlwaysUseCrossGen2 Condition="'$(TargetOS)' == 'browser'">true</AlwaysUseCrossGen2>
   </PropertyGroup>
   <ItemGroup>
     <Compile Include="$(MSBuildProjectName).cs" />
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_131635/Runtime_131635.csproj b/src/tests/JIT/Regression/JitBlue/Runtime_131635/Runtime_131635.csproj
index fd618744d88c24..de6d5e08882e86 100644
--- a/src/tests/JIT/Regression/JitBlue/Runtime_131635/Runtime_131635.csproj
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_131635/Runtime_131635.csproj
@@ -1,10 +1,6 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
     <Optimize>True</Optimize>
-    <!-- The bug is wasm R2R (crossgen) codegen, and it only reproduces with optimization
-         enabled. Force crossgen on the browser leg so this actually runs as wasm R2R;
-         otherwise a plain browser leg runs it as normal JIT and silently false-passes. -->
-    <AlwaysUseCrossGen2 Condition="'$(TargetOS)' == 'browser'">true</AlwaysUseCrossGen2>
   </PropertyGroup>
   <ItemGroup>
     <Compile Include="$(MSBuildProjectName).cs" />
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_131640/Runtime_131640.csproj b/src/tests/JIT/Regression/JitBlue/Runtime_131640/Runtime_131640.csproj
index 6de2c94e52efce..de6d5e08882e86 100644
--- a/src/tests/JIT/Regression/JitBlue/Runtime_131640/Runtime_131640.csproj
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_131640/Runtime_131640.csproj
@@ -1,11 +1,6 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
     <Optimize>True</Optimize>
-    <!-- The bug only reproduces when the caller is optimized R2R code, so force crossgen on
-         the browser leg. AlwaysUseCrossGen2 only takes effect through the project's own run
-         script, which requires process isolation. -->
-    <AlwaysUseCrossGen2 Condition="'$(TargetOS)' == 'browser'">true</AlwaysUseCrossGen2>
-    <RequiresProcessIsolation>true</RequiresProcessIsolation>
   </PropertyGroup>
   <ItemGroup>
     <Compile Include="$(MSBuildProjectName).cs" />
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_70259/Runtime_70259.cs b/src/tests/JIT/Regression/JitBlue/Runtime_70259/Runtime_70259.cs
index a3ad46606faf48..8c7dcd9ebd9128 100644
--- a/src/tests/JIT/Regression/JitBlue/Runtime_70259/Runtime_70259.cs
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_70259/Runtime_70259.cs
@@ -8,9 +8,13 @@
 using InlineIL;
 using System;
 using System.Runtime.CompilerServices;
+using TestLibrary;
+using Xunit;
 
 class Runtime_70259
 {
+    [ActiveIssue("https://github.com/dotnet/runtime/issues/70279", TestRuntimes.Mono)]
+    [ActiveIssue("https://github.com/dotnet/runtime/issues/133169", typeof(PlatformDetection), nameof(PlatformDetection.IsWasm), nameof(PlatformDetection.IsReadyToRunCompiled))]
     private static int Main()
     {
         // This creates an open delegate that goes through shuffle thunk and
@@ -45,4 +49,3 @@ public virtual int Method()
         }
     }
 }
-
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_70259/Runtime_70259.il b/src/tests/JIT/Regression/JitBlue/Runtime_70259/Runtime_70259.il
index 60bf71c3e47b2f..2daaab5ddeef0e 100644
--- a/src/tests/JIT/Regression/JitBlue/Runtime_70259/Runtime_70259.il
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_70259/Runtime_70259.il
@@ -10,7 +10,7 @@
 // Metadata version: v4.0.30319
 .assembly extern System.Runtime { .publickeytoken = (B0 3F 5F 7F 11 D5 0A 3A ) }
 .assembly extern xunit.core {}
-
+.assembly extern TestLibrary { .ver 0:0:0:0 }
 .assembly extern Microsoft.DotNet.XUnitExtensions { .publickeytoken = (31 BF 38 56 AD 36 4E 35 ) }
 .assembly Runtime_70259
 {
@@ -72,6 +72,11 @@
         string('https://github.com/dotnet/runtime/issues/70279')
         int32(0x2) // Mono
     }
+    .custom instance void [Microsoft.DotNet.XUnitExtensions]Xunit.ActiveIssueAttribute::.ctor(string, class [mscorlib]System.Type, string[]) = {
+        string('https://github.com/dotnet/runtime/issues/133169')
+        type([TestLibrary]TestLibrary.PlatformDetection)
+        string[2] ('IsWasm' 'IsReadyToRunCompiled')
+    }
     .entrypoint
     // Code size       31 (0x1f)
     .maxstack  8
diff --git a/src/tests/build.proj b/src/tests/build.proj
index 884ccfcddb0f79..7ab8c872c38944 100644
--- a/src/tests/build.proj
+++ b/src/tests/build.proj
@@ -280,7 +280,7 @@
 
   <Target Name="CrossgenFramework"
       DependsOnTargets="GenerateLayout"
-      Condition="'$(__CopyNativeTestBinaries)' != '1' and '$(__TestBuildMode)' == 'crossgen2' and !$(MonoAot) and !$(MonoFullAot)" >
+      Condition="'$(__CopyNativeTestBinaries)' != '1' and '$(__TestBuildMode)' == 'crossgen2' and '$(TargetArchitecture)' != 'wasm' and !$(MonoAot) and !$(MonoFullAot)" >
 
     <PropertyGroup>
       <CrossgenOutputDir>$(__TestIntermediatesDir)\crossgen.out</CrossgenOutputDir>