diff --git a/src/mavedb/worker/jobs/variant_processing/mapping.py b/src/mavedb/worker/jobs/variant_processing/mapping.py
index efc8226b..be2fde45 100644
--- a/src/mavedb/worker/jobs/variant_processing/mapping.py
+++ b/src/mavedb/worker/jobs/variant_processing/mapping.py
@@ -173,6 +173,9 @@ async def map_variants_for_score_set(ctx: dict, job_id: int, job_manager: JobMan
 
                 job_manager.save_to_context({"mapped_hgnc_name": target_gene.mapped_hgnc_name})
                 logger.debug("Added mapped HGNC name to target gene.", extra=job_manager.logging_context())
+            else:
+                target_gene.mapped_hgnc_name = None
+                logger.debug("No gene-level info found for target gene.", extra=job_manager.logging_context())
 
             # add annotation layer info
             for annotation_layer in reference_metadata[target_gene_identifier]["layers"]:
@@ -203,6 +206,8 @@ async def map_variants_for_score_set(ctx: dict, job_id: int, job_manager: JobMan
 
             target_gene.pre_mapped_metadata = cast(pre_mapped_metadata, JSONB)
             target_gene.post_mapped_metadata = cast(post_mapped_metadata, JSONB)
+            target_gene.uniprot_id_from_mapped_metadata = None
+
             job_manager.db.add(target_gene)
             logger.debug("Added mapping metadata to target gene.", extra=job_manager.logging_context())
 
diff --git a/tests/worker/jobs/variant_processing/test_mapping.py b/tests/worker/jobs/variant_processing/test_mapping.py
index dc2ac843..bbeafe3a 100644
--- a/tests/worker/jobs/variant_processing/test_mapping.py
+++ b/tests/worker/jobs/variant_processing/test_mapping.py
@@ -333,6 +333,62 @@ async def dummy_mapping_job():
         assert annotation_statuses[0].annotation_type == "vrs_mapping"
         assert annotation_statuses[0].status == "success"
 
+    async def test_map_variants_for_score_set_clears_stale_uniprot_id(
+        self,
+        session,
+        with_independent_processing_runs,
+        mock_worker_ctx,
+        sample_independent_variant_mapping_run,
+        sample_score_set,
+    ):
+        """A remap must clear any UniProt ID left over from a prior mapping run.
+
+        The downstream UniProt job only writes on success, so a stale value would otherwise
+        persist and be mismatched against the newly mapped metadata.
+        """
+
+        async def dummy_mapping_job():
+            return await construct_mock_mapping_output(
+                session=session,
+                score_set=sample_score_set,
+                with_gene_info=True,
+                with_layers={"g", "c", "p"},
+                with_pre_mapped=True,
+                with_post_mapped=True,
+                with_reference_metadata=True,
+                with_mapped_scores=True,
+                with_all_variants=True,
+            )
+
+        variant = Variant(
+            score_set_id=sample_score_set.id, hgvs_nt="NM_000000.1:c.1A>G", hgvs_pro="NP_000000.1:p.Met1Val", data={}
+        )
+        session.add(variant)
+
+        for target in sample_score_set.target_genes:
+            target.uniprot_id_from_mapped_metadata = "P00000"
+            session.add(target)
+        session.commit()
+
+        with (
+            patch.object(
+                _UnixSelectorEventLoop,
+                "run_in_executor",
+                return_value=dummy_mapping_job(),
+            ),
+        ):
+            result = await map_variants_for_score_set(
+                mock_worker_ctx,
+                sample_independent_variant_mapping_run.id,
+                JobManager(session, mock_worker_ctx["redis"], sample_independent_variant_mapping_run.id),
+            )
+
+        assert isinstance(result, JobExecutionOutcome)
+        assert result.status == JobStatus.SUCCEEDED
+
+        for target in sample_score_set.target_genes:
+            assert target.uniprot_id_from_mapped_metadata is None
+
     @pytest.mark.parametrize(
         "with_layers",
         [