diff --git a/Dockerfile-dmpk b/Dockerfile-dmpk
index 0a7ae4f..c7b8135 100644
--- a/Dockerfile-dmpk
+++ b/Dockerfile-dmpk
@@ -16,7 +16,9 @@ ENV PYTHONPATH=/code
 ENV HOME=/code
 WORKDIR ${HOME}
 
-RUN pip install matplotlib==3.7.1 im-data-manager-job-utilities==1.0.1
+# numpy is pinned below 2 because this matplotlib release predates
+# NumPy 2.0 and its compiled extensions are not ABI-compatible with it
+RUN pip install "numpy<2" matplotlib==3.7.1 im-data-manager-job-utilities==1.0.1
 
 COPY utils.py ./
 COPY dmpk/*.py ./dmpk/
\ No newline at end of file
diff --git a/Dockerfile-rdkit-base b/Dockerfile-rdkit-base
index 67204ee..6e9e144 100644
--- a/Dockerfile-rdkit-base
+++ b/Dockerfile-rdkit-base
@@ -13,6 +13,8 @@ RUN apt-get -y update &&\
 ENV PYTHONUNBUFFERED=1
 
 # pip install RDKit
-RUN pip install rdkit==2023.3.2
+# numpy is pinned below 2 because this rdkit release predates NumPy 2.0
+# and its compiled extensions are not ABI-compatible with it
+RUN pip install "numpy<2" rdkit==2023.3.2